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Cells At Work! Season 2 release date confirmed upcoming: Hataraku Saibou manga, Cells At Work! BLACK, Bacteria At Work!, and Cells That Don’t Work! continue the story of the anime [Spoilers]

Cells At Work! fight scene
Cells At Work! Season 2 has plenty of stories left to tell. Pic credit: David Production
  • Updated May 1, 2019: Added Platelets At Work manga announcement.
  • Updated March 23, 2019: Cells At Work! Season 2 confirmed at AnimeJapan 2019.
  • Updated December 20, 2018: Added Crunchyroll announcement concerning Cells At Work! OVA episode.
  • Updated November 27, 2018: Added Cells At Work! OVA episode announcement and additional spoilers.

Cells At Work! Season 2 has been confirmed to be in production at AnimeJapan 2019. A new key visual along with an announcement preview video trailer has been released.

Cells At Work! Season 2 has the opportunity to build on the success of the anime series by expanding into a new body of work. Puns aside, it’s very possible that Hataraku Saibou Season 2 may draw upon the multiple spin-offs that the original series has inspired and go beyond the story of Red Blood Cell AE3803 and White Blood Cell U-1146.

The YouTube trailer is locked to certain countries, so if that doesn’t work try the DailyMotion video.

Not too long after the first season released, a Cells At Work! OVA episode was released in Japan on December 24, 2018. Crunchyroll aired the OVA episode with English subtitles starting December 26, 2018. Titled Common Cold Syndromes, the story is based on manga chapter 11 of Volume 3.

While a chapter about the common cold sounds cut and dry storywise, it’s actually a comedy about a bored common cell teaming up with an infected cell. The story opens up with immune cells being pranked by the two cells. Unfortunately for that common cell, he figures out very quickly that his new “friend” has not-so-friendly intentions. Of course, the immune system saves the day and then the killer T-cells are forced to socialize.

Cells At Work Season 2 Announcement Key Visual
The key visual for the Cells At Work! Season 2 announcement. Pic credit: David Production

This article provides everything that is known about Cells At Work! Season 2 and all related news. As such, this article will be updated over time with news, rumors, and analysis. Meanwhile, let’s delve down into what is known for certain.

Cells At Work! anime praised by real doctors

The Cells At Work! anime is popular even with real-life doctors and scientists because of its accurate portrayal of how the human body works. Dr. Satoru Otsuka, of the molecular neuro-oncology department of Emory University School of Medicine in Atlanta, Georgia, especially loved Episode 7 “Cancer Cell” because it showed how immune cells prevented the initial outbreak of cancer.

“Even from the point of view of a cancer researcher, I think the content was very accurate,” said Dr. Otsuka, who believes that watching the anime can be a “good opportunity to understand cancer in detail.”

In real life, the immune system rallies to fight off early-stage cancer hundreds of times per day. The strong immune system of a young person can keep cancer at bay, but older people suffer from more cell copying errors. Growing cancer cells also eat up nutrients quickly (which was shown in the anime episode), and rapid unexpected weight loss can be an early warning sign.

“You can’t remember with textbooks about living things,” he said, “but with this you can remember. Definitely check out the manga or anime.”

In China, Cells At Work! has become the most popular anime on Bilibili, which is like a Chinese Netflix. It’s been watched about 27 percent more than the Overlord anime, the second most popular anime this season in China. Biology teachers in China were so impressed by the anime’s scientific accuracy that they assigned watching it as homework.

“It helps students understand and remember the biology information they have learned in school, in a much more entertaining way,” said Yang, a faculty teacher at the High School Affiliated to Southwest University.

Hataraku Saibou Anime
The Hataraku Saibou manga continues to deliver up new chapters every month. Pic credit: David Production

Cells At Work! manga compared to the anime

The story of the Cells At Work! anime is based on the Hataraku Saibou manga series by Akane Shimizu. She won the 27th Sirius New Age Award for best newcomer manga and the Cells At Work! manga is her debut work. Serialized monthly in Monthly Shonen Sirius since 2015, the manga has spawned six volumes composed of 30 chapters. A new volume comes out once or twice a year and Cells At Work! Volume 6 was released in Japan on December 18, 2018.

The official English translation of the Cells At Work! manga is being published internationally by Kodansha Comics. Thankfully, the English release is completely caught up with the Japanese manga and even fan-made scanlation projects have released up through Chapter 25. Volume 6 is scheduled to come out in North America on April 16, 2019.

The popular manga series inspired multiple spin-offs in 2017. The Bacteria At Work! (Hataraku Saikin) manga by Haruyuki Kichida is a story about good bacteria and bad bacteria waging war in the intestines. Similarly, the Cells That Don’t Work! (Hatarakanai Saibo) manga by Moe Sugimoto shows what happens when immature red blood cells just wanna be NEETs.

One of the most recent manga spin-off is probably the most interesting premise. Launched in June 2018 by Shigemitsu Harada, Cells At Work! BLACK (Hataraku Saibo BLACK) tells the story of cells living inside a human body suffering from an unhealthy lifestyle since he drinks and eats too much, has insufficient physical activity, and has high stress. It features stories related to smoking, alcohol, STDs, and even erection problems. This spin-off manga is up to Cells At Work! BLACK Volume 2 as of September 21, 2018.

Starting in May 2019, anime composition writer Yuuko Kakihara and artist Yasu teamed up to create yet another spin-off called Platelets At Work (Hataraku Kesshoban-chan). As might be guessed, the new manga will focus on the adorable platelets.

Unfortunately, none of the manga spin-offs have been officially translated into English for release in North America. Scanlation projects have picked up Cells At Work! BLACK, but so far Cells That Don’t Work! and Bacteria At Work! are not available in English at all.

Cells At Work OVA Episode Common Cold Syndrome
The Cells At Work OVA episode will adapt a manga chapter that was skipped over by the first season. – Pic credit: David Production

When studio David Production chose to adapt the story, they went the straight-forward path of following the Cells At Work! manga pretty closely. In the Cells At Work! anime, each episode tends to focus on introducing a different element of the human body. The episodic nature of the story is the same in the manga, with multi-chapter plots being fairly rare.

In general, each manga chapter is adapted into a single episode. The opening episode was the same story as the first chapter, but otherwise, the anime changed up the ordering of the story significantly. Thankfully, the titles of episodes matched up with the names of chapters, so it’s pretty easy to see which chapters were adapted.

  • Cells At Work! Episode 1: Chapter 1 “Pneumococcus”
  • Cells At Work! Episode 2: Chapter 4 “Scrape Wound”
  • Cells At Work! Episode 3: Chapter 3 “Influenza”
  • Cells At Work! Episode 4: Chapter 5 “Food Poisoning”
  • Cells At Work! Episode 5: Chapter 2 “Cedar Pollen Allergy”
  • Cells At Work! Episode 6: Chapter 7 “Erythroblasts and Myelocytes” and Chapter 8 “Cancer Cells Part 1”
  • Cells At Work! Episode 7: Chapter 9 “Cancer Cells Part 2”
  • Cells At Work! Episode 8: Chapter 10 “The Circulatory System”
  • Cells At Work! Episode 9: Chapter 12 “Thymocytes”
  • Cells At Work! Episode 10: Chapter 15 “Staphylococcus aureus”
  • Cells At Work! Episode 11: Chapter 6 “Heat Stress”
  • Cells At Work! Episode 12: Chapter 17 “Hypovolemic Shock Part 1”
  • Cells At Work! Episode 13: Chapter 18 “Hypovolemic Shock Part 2”

Thankfully for fans who want to read ahead of the anime, there were many skipped chapters. To quickly summarize, if you don’t feel like waiting for Cells At Work! Season 2 then you should go read Chapters 13, 14, 16, and 19 through 25. As previously mentioned, Chapters 26 through 30 released in December 2018 as part of Cells At Work! Volume 6.

Hataraku Saibou Season 2 release date

As of the last update, David Production or any company related to the production of the anime has only officially confirmed the production of a sequel. The exact Cells At Work! Season 2 release date has not yet been confirmed.

Once the news is officially confirmed this article will be updated with the relevant information. In the meantime, it’s possible to speculate about when the Hataraku Saibou Season 2 premiere date will occur in the future.

All in all, there are 37.2 trillion reasons for a second season to happen. Joking aside, the anime was one of the most popular anime on Crunchyroll and other streaming services when it aired. From a financial perspective, the Blu-Ray/DVD sales numbers were also very good, almost double that of the My Hero Academia Season 3 disc sales.

The only problem is the lack of source material in the main manga series. By the end of 2018, the Cells At Work! manga will be up to Chapter 30 in Volume 6. That leaves 11 chapters unadapted, which is barely enough stories for producing Cells At Work! Season 2 immediately. But it’s possible the anime could be supplemented from side stories from Bacteria At Work! and Cells That Don’t Work!

On top of that, a Cells At Work! BLACK anime adaptation could be potentially worked into the main series as a series of side stories. The one big caveat is that the story apparently takes place in a completely different body so the two main characters are different. The Cells At Work! BLACK manga already is up to Chapter 10, which is also enough content for a standalone anime.

Hopefully, David Production will have a quick turnaround with Cells At Work! Season 2. The anime studio only has one project listed for 2019 so far and Strike Witches Season 3 is planned for 2020. Let’s just hope the anime production for Hataraku Saibou does not suffer from clogged arteries.

Cells At Work BLACK Manga Volume 1 Cover
The main characters of Cells At Work! BLACK are like a reversal of the main series, with BLACK featuring a male Red Blood Cell and a sexy female White Blood Cell wielding a katana. Yes, it’s all about the oppai in the spin-off. Pic credit: Issei Hatsuyoshi

Cells At Work! Season 2 spoilers

The second season could very well begin with stories about how memory cells help acquire immunity to viruses and how acne bacteria causes pimples. As might be expected, the latter story has an explosive ending. The hysterical antics of Mast Cell and her histamine dumping will also make a return for a bout of dengue fever. Other medical problems like strep throat and hay fever also make an appearance.

One chapter will show anime audiences a wandering platelet who is trying to train to become stronger. While the platelets have always been depicted as young and cute, their leader, Megakaryocyte, is… not so much. She’s more like a baby-packing drill instructor.

Cells At Work Megakaryocyte Manga Chapter 26
Megakaryocyte debuts in Chapter 26 of the manga series and should make for an interesting character in Cells At Work! Season 2. – Pic credit: Akane Shimizu

Chapter 27 will provide more character backstory since it has White Blood Cell U-1146 and Eosinophil reminiscing about their childhood together as they lay dying on the battlefield. The chapter also reveals the true identity of the mysterious poetry-quoting Basophil.

The return of Cancer Cell was promised in the middle of the first season so it would make sense for Cells At Work! Season 2 to end with that fated battle even though that’d put adapted manga chapters out of order. White Blood Cell U-1146, Killer T, and Natural Killer Cell will team up once again to take on this nemesis. Killer T has transformed into Memory T Cell and thinks he can easily predict Cancer’s actions, but Cancer has a new trick up his sleeve… and a new ally?!

Those chapters also introduce the concept of good and bad bacteria living in the intestinal tract. Therefore, it would make sense to incorporate the side stories from the Bacteria At Work! manga into the main anime series once that introduction is made.

Whether or not David Production decides to adapt the spin-offs along with the main manga series, let’s just hope we don’t have to wait too long for the Cells At Work! Season 2 release date. Stay tuned!

Patrick Frye is Monsters and Critics' Anime Editor. He considers himself a "woke-taku" and he enjoys covering all the latest news related to Japanese entertainment.... read more


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