Amnesty said it interviewed several victims of the so-called practise of rendition and said their statements matched factual data checked, such as flight information.
Also consistent was the description of incidents of torture and other ill-treatment, the organization added.
The human rights watchdog said it had analysed the movements of aeroplanes directly linked to the US secret service between 2001 and 2005, specifically the aircraft that transported high-profile rendition victims such as Khaled el-Masri, Maher Arar and Abu Omar.
'The analysis shows that these aeroplanes often used European airspace, although it does not prove that they were always transporting prisoners,' Amnesty underlined.
EU member states must ensure that European airports and European airspace are not used to support or facilitate renditions, the human rights watchdog said.
'With or without diplomatic assurances, this practise is not about bringing people to justice, it leads to torture and puts lives at risk,' it added.
Meanwhile, a European Parliament committee probing alleged secret CIA actions in Europe, on Tuesday criticized national governments for obstructing its efforts to cast light on the sensitive issue.
'There is a list of documents and invitations to governments that have not been replied to,' said British Socialist Euro MP Claude Moraes, adding: 'This is emerging as a key weakness in our inquiry.'
'We have asked for the outcomes of national inquiries into these matters but so far we have not received any report,' said Austrian Socialist Euro MP Wolfgang Kreissl-Doerfler.
Continuing their inquiry, members of the EU parliamentary committee will go on a fact-finding mission to Macedonia next month to investigate charges by Lebanese-born German national Khaled El Masri that he was kidnapped by the CIA in Macedonia and held captive in Afghanistan as a terrorism suspect in 2004.
In May, EU lawmakers will travel to Washington to quiz US government officials. The committee also plans talks with German secret service officials and Foreign Minister Frank-Walter Steinmeier, who headed the office of former German Chancellor Gerhard Schroeder.
The former German government, which strongly opposed the US invasion of Iraq, has denied complicity in the case of El Masri who claims that a German interrogator questioned him at a US prison in Kabul. Munich state prosecutors last month launched an investigation to determine whether Germany secretly helped the CIA in the abduction of El Masri.
The parliamentary committee investigating the CIA charges was set up in January. It is working in tandem with an inquiry by the Council of Europe inquiry and intends to present its first findings by the end of June. However, the committee has no power to sanction European governments.
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